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81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little was known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor in a physiologically gewöhnlich pathway and not necessarily in a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.

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You want to get your driving licence hinein Munich as soon as possible, in an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support rein theory, practice and other aspects of training.

The law prescribes attendance of 12 Beginners all purpose symbolic instruction code themes and two additional themes (irrelevant which); but you are recommended to have heard all the themes.

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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass welches the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He was also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.

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We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. In this way you will get your driving licence as quickly as possible.

You are allowed to have 10 negativ points. You have failed the test if you get 11 or more negativ points. If you incorrectly answer two questions each with five minus points, you have also failed the test in spite of not exceeding the maximum number of negativ points; rein Class B, questions with 5 points have a greater relevance hinein the theoretical test.

Chris­t­ian Haass, Profes­sor of Metabolic Biochem­istry at LMU Munich and spokesper­son for the DZNE Munich, is known for his ground­break­ing research rein Alzheimer's disease. His work focuses on the molec­u­lar and cellu­lar mecha­nisms of this disease hinein order to gain funda­men­tal insights into its devel­op­ment.

Next to the Ostfriedhof bus and tram stop Can I take a trial lesson rein the theoretical course hinein order to get an impression of the atmosphere?

Chris­t­ian Haass is a German Biochemist and known for his work on the cell biology of neurode­gen­er­a­tive diseases.

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